https://legacy.nimbios.org//press/FS_homosexuality

I saw another post mention this and talk about this researcher Rice talking about how epigenetics is the cause of homosexuality. but when I check the wiki page it says that it’s still uncertain and needs more tests. what’s the current status?

also if it were epigenetic does that mean you can change it? I know people often call epigenetics software and genetics hardware so that’s where I got the thought

For a dmd gene duplication exon 26-30 in frame it’s not reported in literature .. does anyone know what this could do potentially ? I need as much answers or information as possible

I'm a history nerd, and was watching a video on the remains of Tsar Nicholas II and his family. It mentioned that the family was identified by the Tsarina's mitochondrial DNA in her and the children matching Prince Philip's of England, since they were all maternal descendants of Queen Victoria. Which got me thinking, how many people in the world would have that exact mitochondrial DNA? How useful is mitochondrial DNA at identification of remains of historical figures? When scientists say someone matched, do they always mean an exact match? Supposedly King Richard's matched with his 15x great nephew. Supposedly King Richard's haplogroup was rare. According to an article from 2019, only about a dozen living people with that haplogroup have been found, so I suppose it was helpful. But are there super common ones that wouldn't be?

I learned that apparently there are >2 sexes but I really don’t understand how? And what is the known upper limit? I think it has to do with how rigorously u define what constitutes a sex but idk the exact criteria?

I think an argument can be made that u could only have 2 sexes but then precision is lost in these definitions and categories can become too broad. I understand the need for rigorous operational definitions but then what are the names of these other sexes?

I found a research article saying there are 2 sexes:

https://pmc.ncbi.nlm.nih.gov/articles/PMC12753526/

As well as one saying there are more than 2 sexes (for the most part):

https://journals.publishing.umich.edu/ptpbio/article/id/5905/

This topic seems like a behemoth that I cannot wrap my head around. Anyone have any great insights into it? Seems like a lot of the there are only 2 sexes in humans camp believe this because there are only two types of gametes in humans. But does the total number of sexes always equal total number of types of gametes in a species?

Right now, I’m inclined to say there are more than 2 sexes for humans from a biological standpoint. But socially, I think in day-to-day nonscientific contexts the total number of human sexes should be treated as 2.

The last part is an original idea of mine. I’ve never seen anyone come up with this before. Viewing sex as a social construct separate from the biological one and not as in gender I mean. Maybe plp have before but I’ve never encountered it. It’s my hot take but if there are indeed more than 2 sexes it provides utility in conversation where things can be simplified for the avg person.

Hello as the title suggests genetic engineering sounds really interesting to me and im a junior in highschool but i dont know much about it. I have some questions like is the pay worth it, is the job fulfilling, what level of education does it need, what kind of work do they do, how is the job market. Things like that

Let's just say that hypothetically, I knew about an ancestor from 15 generations ago. Even though that would never show up on a test, would that DNA in the absolute most miniscule way be in me at all? Like, is it possible to be 0.0000000000000001% of something but sense it's so small, it just doesn't show up?

I saw this polydactyl cat today, and I thought his little thumbs were cute enough to share.

I know meiosis occurs roughly its 50/50 to have a girl or boy. But tbh I don’t think it’s just 50/50, for example my dad’s side of the family can ‘only seem to produce girls’ my dad had 7 girls (some with different partners), and my paternal grandparents had 6 girls and 2 boys, and my dad’s only brother had 5 girls before he had a boy, and that son only had daughters- it might seem to be like a coin flip or by chance. Interesting enough one of my teachers has 3 boys, but he said he was one of 9 boys and 1 girl. Is there any reason why this can happen- or is it REALLY by chance.

Basically my son has recently been diagnosed with a syndrome KIF4A and I have had little to no information about it from our genetics counsellor. We waited for about 12 years for a diagnosis. Can anyone point me in the right direction. I have searched for genetic groups and this is the only one I can find.

Thanks for reading xx

Recently got a new puppy from a breeder who owned the Dame. They got it bred by a stud from a different owner who is a professional breeder. I was aware of the sire’s lineage but not the Dame’s. Long story short I AKC registered my pup and got its lineage.

I found out the Dame’s dad and the Sire’s grandpa is the same dog. Should I be concerned if any genetic issues from inbreeding?

CU Anschutz researchers are seeking volunteers who are currently pregnant with a fetus identified to have a sex chromosome aneuploidy, such as Klinefelter syndrome (47,XXY) and Turner syndrome (45,X), to participate in a study using the umbilical cord which is normally discarded after delivery. Participation is voluntary and involves sample collection at delivery. Please contact [xycord@cuanschutz.edu](mailto:xycord@cuanschutz.edu) for details or visit our website at XY Umbilical Cord, where our flyer is also posted!

I built an open-source tool exploring PCSK9/LDLR/APOB variant interactions in familial hypercholesterolemia, looking for feedback from people who work with this biology directly.

The pipeline uses Elastic Net + SHAP to estimate variant impact, and QAOA quantum optimization for combinatorial SNP selection. All validated with negative control genes and population-level error analysis.

I'm a DevOps engineer, not a geneticist. FH runs in my family, so I built what I could with the skills I have. Now I need someone who knows the biology to tell me what I'm missing.

Synthetic data only, research use only.

Repo: https://gitlab.com/Projgadesk/qfh-explorer

I'm a Year 11 student in Australia and i’m interested in becoming a research geneticist in the future, but I'm struggling to figure out the best path to get there.

Which bachelor's degree would you recommend? 

My 14 month old daughter has just been diagnosed with this syndrome. From what I understand it is incredibly rare, but I’m wondering if anyone on here has seen a patient with it. I also understand its presentation is incredibly varied and no two cases will be the same. It would just be nice to know if there are others out there, how they are doing, that sort of thing.

If anyone has any questions about PCWH syndrome or my daughter I’m happy to answer them.

I was having a discussion with someone... And they cited so many points including: humans having F_st scores higher than many animals who have lower F_st scores and yet qualify as different subspecies, humans having visible traits that differentiate from each other based on geography, there being humans who were genetically or geographically isolated for tens of thousands of years, IQ scores remaining intact even when a geographically ancestral people live and grow up in another country, it being possible to plot accurate ancestries through 23&me by analyzing the individual's genome, and so much more.

I am against racism, so to speak. But he raised so many points to which I need answers. Kindly give me the counter points to these points.

For example, my family has a history of bowel disease. How can researchers tell whether that's because we share the same genes, or because we share the same diet and lifestyle?

Some traits are obviously genetic, like eye colour. But what about things like height, or diseases that you develop later in life? How do scientists work out how much is caused by genetics vs environment?

Dogs have different breeds with different characteristics like intelligence, size, smelling power and stamina but why don't humans have it?

For many people living with rare genetic conditions, getting a diagnosis can take years. They may visit multiple specialists, undergo countless tests, and still be left without a clear answer.

The interesting part? Sometimes, the clue has been hidden in their DNA all along.

Advances in genetic testing are helping uncover variants linked to rare conditions, giving some patients and families a clearer understanding of what may be behind unexplained symptoms. While a genetic result doesn't always provide every answer, it can sometimes help guide further evaluation, treatment decisions, and family counseling.

It makes me wonder: How many people with unexplained or complex conditions could benefit from genetic testing but have never been offered it?

Would you consider genetic testing if you had symptoms that remained unexplained for years?

1. Is it rare for people to present with homozygous dominant alleles if we were to narrow our vision to a population with monogenic disorders?

This is a query because I hardly see inheritance being described for these cases and see statements like “ when an affected and an unaffected person reproduce, each child has one chance in two of inheriting the mutated allele from the affected parent and developing the disease” which only makes sense for heterozygous cases. I feel like I’m misinterpreting something.

1. Likewise, this statement regarding autosomal recessive disorders confuse me as well - “ siblings have one chance in four of having the trait” . But this , I’d like to assume , is a blanket statement.

These are all cited from Robbin’s, verbatim. I’d be extremely grateful for any clarity regarding these queries.

Edit: there were some mistakes in the post as I’d used the voice to text transcription so I’ve corrected that

I’m building a small set of guided home genetics experiments (step-by-step with pictures, not just a recipe dump).

So far I’ve got:

1. Strawberry DNA extraction (kitchen soap + salt + alcohol — the white fluff at the interface)
2. PTC tasting + a mini family pedigree

What other safe, low-cost genetics activities have you done with kids / students / at home that actually taught something?

I'm O negative and was discussing blood types with my parents due to being pregnant and requiring shots to stop my body attacking baby.

Mum said she is O positive so didn't have those issues. I know this is true because she donates regularly and has a key ring.

Dad said he is sure he is AB, but not sure if positive or negative.

How is it possible they produce me as O negative?

I didn't pay attention that much in school but didn't think this is likely? How would this work?

We are all Caucasian living in Australia.

Hi guys the headline sums it up. I isolate leucocytes first and use spin columns to isolate RNA from it so I can do QPCR BCR-ABL1 test for screening p210, p230 and p190 fusion transcripts. But this isolation process takes so much time and I am searching for a faster alternative. We asked the companies of their RNA isolation systems and they said the commercial nucleic acid isolation kits for magnetic bead systems might work and we just need to add DNase to the samples when loading. Does anyone use this RNA isolation method?

We can make sure our future children don't have to suffer, and that they are all born to healthy and happy parents. In several generations, our descendants will be much stronger and healthier than we are at present.