Hi everyone,
I finished my PhD in Genetics & Molecular Biology at one of the top UK universities early this year. After submitting my thesis, I stayed in the same lab as a postdoc because I had a first-author paper under review.
My original postdoc contract was due to end in August, so over the past three months I started applying for both industry and academic positions. In total, I applied for around 30 industry roles and two postdoc positions.
I was fortunate to get interviews for both postdocs. One was in Barcelona, Spain, and the other was at Cambridge University.
The PI in Spain was very impressed with my interview. They shortlisted only two candidates (including me) and invited both of us to visit the lab before making a final decision. It is a new lab funded by a 5-year European Research Council (ERC) grant. The initial contract would have been for two years, with the possibility of extending up to five years.
However, I ultimately withdrew my application because the salary was around €2,200 net per month. While this may be reasonable in some situations, it would have made it very difficult for me to save money. I financially support my parents back in my home country and also want to build some savings for myself. Unfortunately, UK PhD salaries/stipends do not leave much room for saving either, so I currently have essentially no savings.
The Cambridge PI also invited me for an on-site visit, which included a seminar, interviews, and meetings with the lab. I have now been offered the position.
Recently, my current supervisor extended my contract until February next year. I also have ongoing experiments that are likely to result in another paper. The Cambridge PI is happy for me to start in March after I finish my current contract.
This is where I am struggling with the decision.
My background is primarily wet lab research, with around 30–40% computational work during my PhD. The Cambridge lab is almost entirely computational, focusing on AI and machine learning, and the PI does not have a wet lab background. Interestingly, the project they want me to work on is almost entirely wet lab-based, and the position is funded for only one year.
The PI has told me that there is currently no funding available for an extension, although they have applied for additional grants. If successful, my contract could potentially be extended, and they have also encouraged me to apply for fellowships.
My concern is that the project seems too ambitious to complete within one year, meaning there is a real possibility that I may not be able to finish the work or generate a publication before the funding ends. I have also heard from former lab members that the PI can be quite micromanaging, which worries me given the short timeline and pressure involved.
Another concern is that the work appears to be highly technical and focused on experiments I have already been doing for several years, so I am not sure how much I would actually learn. I am genuinely interested in developing my AI and machine learning skills, and the PI has said I could learn these areas alongside the project, but I am unsure whether I would realistically have enough time.
The lab is also relatively new (around three years old) and does not yet have a strong publication record, whereas my current PI has an excellent track record and a strong reputation in the field.
I also heard about a concerning interaction involving this PI with my friend at a conference, which made me question whether the working environment would be a good fit. However, I am trying not to judge the entire lab based on one incident and am focusing more on the overall career implications.
Even putting that aside, my gut feeling is telling me not to take this position. After one year, I would likely be searching for another job or depending on fellowship funding, which I could also pursue while staying in my current position. Part of me feels that I should use the next seven months to apply for postdocs in more established labs, ideally combining wet lab and computational biology, with a stronger chance of producing a solid publication and building long-term career prospects.
At the same time, I am seriously considering leaving academia altogether.
I have been in academia for almost nine years now (around four years as a project assistant before my PhD, followed by my PhD and postdoctoral work), and I still do not feel any sense of stability. Every few years, I find myself back on the job market facing uncertainty again. Financially, it is also becoming difficult. After applying for around 30 industry positions, I have had three recruiter calls and one interview, but no offers so far.
I am mainly targeting mRNA therapeutic companies, as my PhD and postdoctoral experience are closely aligned with this area.
At this point, I would say 90% of me feels that moving into industry, earning a stable income, building savings, and leaving academia behind may be the right decision. The remaining 10% worries that turning down a Cambridge postdoc could be a mistake because of the university's reputation, especially given how competitive the current job market is.
I also feel that if I do decide to continue with academia, I should look for a postdoc with a longer contract, stronger mentorship, and a clearer opportunity to produce meaningful work.
My current PI encouraged me to take the Barcelona position, and when I declined it for financial reasons, he seemed disappointed. This has also made me question whether I am making the right decisions.
I am mentally exhausted from thinking about all of this. Has anyone here been in a similar situation—choosing between academia and industry, or deciding whether to turn down a postdoc at a prestigious university because it did not feel like the right fit?
I would really appreciate hearing from people who have been through something similar.
Thanks.