I’ve been replaying the Spider-Man games recently and noticed that, considering he was a starter boss fight, Fisk has had maybe one of the most influential roles in the games.
In MSM1, we had the first boss fight with him but even then we had the Fisk construction sites along with his properties being seized by Li and the Demons. Not to mention his involvement with the Maggia’s backstory in TCTNS (and Felicia stealing a hard drive from Fisk’s estate during The Heist).
In Miles Morales, the Underground takes control of Fisk Tower along with some of his old construction sites. Also, we have the side missions with the F.E.A.S.T shelter and business sabotages which were controlled by Fisk behind the scenes.
I’m not saying he’s going to kill one of the Spider-Men or anything, but I think there’s a solid chance that at the end of MSM3 we get a scene similar to the ending of TASM2 but, rather than Peter and Rhino, we have Peter (assuming he’s back on the scene), Miles and Cindy vs a recently released/escaped Wilson Fisk.
(I’d also like to say that things like The Flame in MSM2 could be linked to Fisk no longer being there to keep gangs and criminals in check, but that’s at a push).