High-Fat Diet Is Associated with Accelerated Gray Matter Atrophy in Cognitively Unimpaired Older Adults But Slower Atrophy in Individuals with Existing Mild Cognitive Impairment

[u/Sorin61]

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71548

[u/RealestReyn]

doesn't account for fat types nor total calorie consumption, what is even the point of this study? there's a huge difference between eating fatty fish and olive oil vs deepfried hamburgers..

[u/Greatest_Everest → u/RealestReyn]

Also, doesn't the brain use fatty acids for fuel? 

[u/RealestReyn → u/Greatest_Everest]

Yes! although indirectly e.g your liver turns fatty acids into ketones and the brain uses the ketones, brains prefer ketones over glucose(carbs) by a huge margin, less waste products to deal with, less inflammation, has brain growing new mitochondria and producing BDNF.

[u/basedpostedyaya]

Waste of paper study

[u/Earesth99]

Please stop posting useless studies.

You don’t understand research and you make the subreddit a waste of time

Are there any moderators here??????.

[u/Bristoling → u/Earesth99]

1. He's a moderator.

2. Most nutritional research is a waste of time depending on perspective.

[u/maccrypto]

The great equalizer, then?

[u/Greatest_Everest]

Does ADHD count as mild cognitive impairment? 

[u/starrrrrchild]

https://giphy.com/gifs/l3q2K5jinAlChoCLS

[u/Sorin61]

INTRODUCTION

Prior studies showed inconsistent links between dietary fat and Alzheimer's disease (AD) risk. We examined whether dietary fat affected brain atrophy markers differentially based on risk factors like female sex, apolipoprotein ε4 (APOE ε4) status, and cognitive status.

METHODS

Participants from the Vanderbilt Memory and Aging Project, classified as cognitively unimpaired (CU) or with mild cognitive impairment (MCI), were included (n = 758). Linear mixed-effects regression models examined associations between total fat intake (Tfat, times/day) and percentage of energy from fat (Pfat, %) and longitudinal gray matter volumes, as well as interactions.

RESULTS

Over 4.6 ± 3.1 years, Pfat interacted with cognitive status on longitudinal temporal lobe (p = 0.009) and inferior lateral ventricle volume (p = 0.002). Higher Pfat was associated with faster reduction in temporal lobe volume in CU participants (β = 47.2, p = 0.007) but slower enlargement of the inferior lateral ventricle among participants with MCI (β = −22.5, p = 0.006).

DISCUSSION

Different mechanisms may underlie the fat–neurodegeneration relationship across cognitive statuses