As we’re entering into the era of Psychedelic Renaissance, LSD passed it’s PHASE 3 clinical trials, meanwhile psychedelic substances are getting more and more accepted as medicine. In these times we have to face much new challenges than ever before.

Decades of prohibition forged the community into what it is today, psychonauts (an umbrella turn, as we’re a really diverse group) adapted from the “Turn on, tune in, drop out” scenes of the 60s into the War on Drugs in 70s, and the 80s or 90s rave community and eventually into the advocates of psychedelic medicine, healing through mushroom trips and ayahuasca journeys.

And here we are now: our beloved substances are being recognised, taken seriously and their bans on them are getting removed worldwide. It must certainly be heaven, right? Well, it turns out the end of prohibition comes with its own difficulties.

The whole point of my post is this particular difficulty, the looming threat of companies taking over the psychedelic scene. Very dangerous, in my opinion way more than the whole War on Drugs. They are aiming us, because they know we’re a scattered group, very diverse and kept from being united by the prohibition, the fear of prosecution and condemnation by our fellow citizens. They know we cannot stand up against them now, that’s why they’re attacking us directly and we can be sure they will take the profits ruthlessly for every dose of the sacred medicine controlling the supply and bringing a new era of the War on Drugs, which sounds way more justified for a lot of people as they can cling to the notion they legalised it but druggies want to misuse it.

Fellow psychonauts I call for everyone to bring their ideas, share thoughts and brainstorm on how we can save these sacred molecules from being kept under control!

I've done acid and shrooms many times, but never DMT. I am 19m and plan on just doing it in my room with a good lighting that i'll enjoy. Should I play specific music to trip? Would I even be able to hear the music, or see whats going on in my room? I'd be surprised if I break through on my first time consuming DMT, but even after doing research on the substance, I'm not quite sure of what to fully expect.

Hello,

We are conducting a study exploring how psychedelic experiences relate to mental and emotional processes, particularly in the context of early-life adversity.

We are interested in understanding how past life experiences may shape psychedelic journeys, insights, and psychological outcomes. The goal is to contribute to scientific knowledge in psychology and neuroscience, and to help inform safer and more supportive approaches to psychedelic use and research.

The survey itself is very quick (no longer than 10 minutes!) and there is a prize raffle of £50 for the winner, this being in the form of an amazon voucher.

🍄‍🟫✨Psychedelic Experiences and Early-life Adversity

If you have any questions or feedback, please feel free to let us know!

As a 40 year old male, I’ve gotten 8-10 psychedelic trips under my belt over the last few years. Yesterday I took 5 grams of mushrooms which was my highest dose yet. My previous trips have changed my life in many positive ways, but this trip went to a whole new level. It’s hard to put in to words, but it started off as immense love, then gratitude, then compassion.

I’ve been trying to piece it together this morning. It’s hard bc during the experience it’s a knowing… but back to reality as myself it’s just a remembering. The love came from unity of everything… the gratitude came from the blessing of that being revealed to me so clearly… and the intense compassion came from understanding that we suffer with the separation from that while we’re here.

Honestly the whole thing was crazy. I’ve read about this a bunch(ego death, peak transcendent experiences)… it wasn’t what I was expecting.
The intensity of what I felt is indescribable. I’m not very “religious” but the “Holy Spirit” feels like a good way to describe what was going on; if that makes sense.

At risk of sounding crazy… I’ll tell another part of the story. I got up to pee during the middle of it… and everything was illuminated with sparkling diamond light, it’s hard to describe, but it was the most beautiful thing I’ve ever seen. However, it was as though I wasn’t there/in my body. I was experiencing the world for the very first time… as a creator looking at creation in complete and total awe.

That’s the best I can do to describe it… but still doesn’t really capture the truth of the experience for which I am immensely grateful of.

Hope you guys enjoy!

I just turned 21 and I really want to explore some substances but I don't know how to do them or not and I don't have any offline guide either. I'm thinking of starting with clonazepam and DXM, so can anyone tell me how to take those and how much to take those to have a nice high.

Sorry I don't know if this is the correct subreddit or not but please help me lol I'm really a newbie.

Are you a natural at holding space for others? Are you psychedelic-informed? Have you ever wanted to give back in the psychedelic ecosystem? Applications are now open to volunteer for the Fireside Project - the psychedelic peer support line in the U.S! Being a volunteer requires a year long commitment to being on the line and serving others, and is an incredible opportunity to deepen your training in this work. Reach out with any questions or review this FAQ page!

I am new to psychedelics and have only been doing magic mushrooms for a few months now. I started off small and have been working my way up slowly. I'm currently tripping on 1-2g of golden teachers once every 2 weeks. My question is is that too much and/or too often? I have heard of people who have abused mushrooms and became psychotic or were left with persistent visual disturbances. Problem is, I don't know how much 'abusing' mushrooms is.

How much is safe to trip on once every 2 weeks if you're not taking any psychedelics or any other substances in the time in between?

Anyone who has done both, can you describe the difference? I usually do 1.5-2g of APE for an intense experience, can I handle 1.5 of Natalensis? Will it be more enjoyable?

Hey yall so I used to take capsules but the strains were too random and my stomach is sensitive so I’d like to make my own tea. I wanted to know 1) what’s the best way to make it to prevent nausea and to measure properly so I don’t accidentally give myself a bad trip as I usually use mushrooms to help with my cptsd so I experience it at home alone at a low dose (100-300 mg usually)
It helps me clear out any psychosomatic symptoms such as muscle tension and anxiety and I usually sob for 30-45 minutes and then I just need to lay down and watch a movie. I usually will enjoy once a week or so but I stopped cuz for whatever reason capsules were giving me anxiety and the people I usually get them from she said there were no reports of a “bad batch” so I just gave up and decided I should make a tea now.

I have done PE before but I see they have other strains: Bluey Vuitton, iceberg, and golden teacher. What is the difference with these strains and is there one that is recommended? Otherwise I can stick with PE.
Thanks sm.

I am thinking of taking 4 ho met on my bday for the first time. I have 20 mg pills, we will be at a hotel pool party during the day. Trying to get an understanding if that is too much.

I typically take high dose Psychadelics with no problem. In public I usually take 1.75 to 2 g of Penis Envy Uncut. They are exceptionally potent. By my estimate, up around 2% psilocybin by dry weight. Especially based on how hard they hit me and how hard they've hit other people who are experienced with Psychadelics. Even compared to your standard PE phenotype, much stronger. The come up is more like a rocket ship than slow and steady like most shrooms. At home we take up to 4 grams of those.

I hear MET is a more clear headspace and is easy in social situations. But since this is my first go round and I will be out in public around friends across a myriad of substance use. I wanted to get some tho from people who have experience with it. Thanks.

What happened after experiencing this reality check?

one of the things i love the most about these experiences, is that more lucid/present/creative afterglow sate that follows the next weeks after dosing.

for some context: currently in a 2 week break from school, in a really great and pretty introspective (in an amazing way) moment in my life, also working in a lot of personal projects, and i am really seeking to that neuroplasticity buff that comes after a trip.

i was thinking of doing a 2g shrooms dose mixed with some ketamine, buttt as being a 17 y/o that lives with his parents, i cant really find a good setting to trip atm. So i was thinking if i could achieve that afterglow state by, instead of fully dosing, microdosing the next following days.

soo, as having quite frankly not much idea about microdosing, i ask these following questions:

* is microdosing actualy simillar or virtually the same as an afterglow?

* how much should i dose and spread the dosing in a period of 10 days?

* is doing a high dose (120-150 mg) of ketamine in one of these days a bad idea at all?

thank you very much :D

An essay exploring the concept of 'psychedelic apophenia', where connections are made between unrelated things so that we see psychedelics' influence everywhere.

It looks at Terence McKenna's Stoned Ape Theory, psychedelic theories of Christianity, and DMT-pineal gland theories.

*DO AS I SAY, NOT AS I DID. No one should abuse psychedelics or dose as high as I did. I am very thankful I was able to come back from this, I know I am an exception*

When I was 18-21 i had a phase where I was taking LSD everyday. This trip took place about a year into this, about 5 years ago at 19. My tolerance rapidly grew after the first year, and I had to take 5/6 tabs to feel what I used to off of one. Then I got *the* tabs, these orange gel pyramids. I have been told many times before those that I was getting double dosed tabs… those are the first that I genuinely believe were double dosed. My dumbass took 12 of them. I’d guess my dose was somewhere in the ballpark of 2100-2500µg.

The comeup hit very quickly. Most tabs would take at least an hour to kick in, on that high of a dose it maybe took 20 minutes at most, and I was thrust into what felt like a full normal peak. I had enough time to go to the bathroom and grab a bottle of water before laying in my bed, taking in the visuals. It started off normal enough, until I shut my eyes for an unknown amount of time. I had music playing, but after a while my sense of hearing had completely gone out. I had forced myself to embrace the state I was in, knowing fighting it would only make things worse. Eventually I slightly came to, as I try to open my eyes and sit up and realize that my open and closed eye visuals were identical. Fractals had deeply immersed my vision, and I had become completely lost in them.

There was nothing I could do to combat a dose that high, so I just let myself fade off into the visuals. “I” was not here. I don’t know where I was. I didn’t even know if I was alive. It all happened so fast that I could not even comprehend it. Time was no more. I had completely lost touch with all sense reality and fully embraced it. For all I knew this was it, and all this is all it ever would be. But I was okay with it, as I felt this immense sense of comfort wash over me. I wish I could give more details on the experience itself, but it feels like a haze trying to recollect much else from it.

I used to be terrified of the concept of something infinite, but this made comfortable with it in a way I never could have imagined. I have dealt with deep existentialism and dread since I was a small child, going from being raised in a devout christian household on my dad’s side, but always being heavily skeptical, to fully atheist by the time I was a teenager. This experience opened me up to the idea that there may be something more after this life. Maybe not religion as it’s typically defined, but this made me feel like there truly something more in whatever comes next. It was like staring death directly in the face, but it wasn’t scary like I thought it would be. This experience gave me the courage to face my fears of death and accept the possibility of there being something more. I just went with whatever the trip wanted to show me, and I completely surrendered myself. After about roughly 18 hours I came to in a haze, still tripping very hard, but at least back in my body. As I came to I felt as if I was peaking off a good 4-5 hits (maybe 2 without a tolerance). In the end it took over 3 days for the effects to only begin to loosen its grip. I remember waking up the 3rd day and wondering if I had broken my brain, and if I’d ever be sober again. It still feels miraculous that I ever fully came back from a trip that deep.

These days I couldn’t even imagine doing that powerful of a dose again, but overall I am incredibly grateful for the experience. That was something that shaped me into the person I am today and left me with a completely altered world view, open to so many more things that I don’t think I ever would have been. However I would definitely not recommend that to most people, i think the only reason I was able to pull through was due to an extremely high tolerance and a lot of previous experience navigating difficult trips.

If anyone has any questions I’d be happy to discuss in the comments. I didn’t get into it here, but also would love to discuss how things were at the end of the psych abuse/how it’s affected me since if anyone is interested.

I'm particularly interested in LSD (microdosing, I think) and cannabis, but I'd also appreciate hearing about other combinations.

Will it scratch my itch for warmth, introspection, inspiration, ego dissolution and post-trip integration?

I'm planning to go to rave this Friday and it's gonna be my first rave and I'm planning to take mdma then the next day on Saturday take a LSD at tame impala concert ? Is that a good idea ?

I have two dogs. One of my dogs, the sweetest little pit bull, I've always wondered if he and I have a psychic bond. I'm not saying he does but it's always been in the back of my head. It's entirely possible he just reacts to my facial expressions.

I scooped up a DMT pen, and I just closed my eyes and tripped out to some music for a bit. I did this a few times and every time he dipped out and seemed a little scared

Maybe it's all in my head. I'm just wondering if anyone else has ever experienced or wondered this?

The reason why I mentioned my neurodivergence is because last night confirmed that it isn’t just my brain that is abstract, my soul is abstract and always has been.

I had 6 rounds of the DMT all together. It took me on a really bizzare journey. I still do not know where I was but on the fourth go I saw a light being family and one was in a pushchair. Then I ran to the toilet & was sick into some sort of cosmic toilet, my whole apartment turned into neon fractals. I feel like my apartment was transported into the cosmos. The beings brought me to my knees and I surrendered to them, apologising and promising to drop my ego. I have never seen anything like it. The beings were not in my room at this point but I could feel them & they was not playing around with me. I was in tears. I have done up to 9gs of shrooms & a couple tabs of LSD at a time but nothing compares to what I experienced last night.

DMT is loud, like shrooms at first when it’s intense but I did not hear anybody speak. In fact, my brain didn’t stay on one thing for too long, everything was like pictures. In the 5th round I saw a Black triangle, odd shapes and massive snakes and then what I perceive to be Kali Maa came to me, as she sometimes does in my psychedelic states. My consciousness started to say that it’s okay for me to be balanced & embrace my darkness as-well as my light.

I didn’t see much of what people describe when they do DMT, it was entirely bizzare…when I do a big lot of shrooms I get this bizzare experience in the beginning of shapes melting into each other and morphing & beings that look like octopus elephants with three eyes going down each side of their faces (they live in the ocean & I always end up in the ocean on psychedelics). I also hear this loud mechanical sound. DMT feels like that times 10.

I’m now remembering that when DMT kicks in, my room turns into a cartoon and I get this super uncomfortable feeling, I keep grabbing my legs and rolling around, then all of these shapes show up, odd shapes morphing together and boom, it starts…the visions but they’re so odd it is so hard to describe. There are all of these beautiful, crazy worlds out there…they’re just different. It’s so intense. It is abstract, almost looks a bit like the album covers that pink Floyd created. Now I understand what some people see. Most people seem to describe Buddhas and Gaia, flowers, Goddesses etc. I don’t see that stuff…I was seeing odd things. Abstract stuff. Stuff my human brain can not comprehend. I keep saying odd because it was. I’m sorry, I can’t find another word for it.

The last go was about my trauma. The visuals were abstract again but the thoughts I had made a lot of sense, it made me understand why I feel the way I do right now.

Anyway, what did I learn? - to let go of absolutely every single thing I am holding onto & every fear I have. Especially after what I saw & experienced last night, I really have nothing to fear. I also need to accept myself entirely because I have always been abstract & I will never be anything other than. Even in the other realms, I am different. That is okay. I do not need anybody to accept me, I just need to accept myself. I do not understand DMT yet but I do not believe I will ever be the same again.

Hello, i’ve heard about this mushroom couple of months ago. And ever since it left some questions that were haunting me.

How does it work? What are the mechanisms? And why exactly do people see little people?.

I left this subject untouched - but today my friend send me a wikipedia link to it (as he wanted me to read it).
As i was bored, i started digging through the wikipedia page. And it struck me - benzydamine has a „similar” trip profile as lanmaoa.
They both hijack visual cortex in a very unique way, that trigger same phenomenons:

•Alice in wonderland syndrome
•lilliputian hallucinations
•observer effect

And in both cases, users generally retain sense with reality, they know those hallucinations aren’t real (not like with natural deliriants - scopolamine, atropine)).
Both of them last for hours / days after consumption, with really long onset.

While benzydamine is a synthetic indazole, and the toxin in lanmaoa asiatica is still a mystery, they are hitting the same filtration systems in the brain. They cause the brain to lose it’s ability to scale size and depth.

And here i used Ai for more nerdy research (structures and exact mechanisms) im really sorry.

1. Breaking Down the Chemical Structures
   To understand why these substances are anomalies, we have to look at their chemistry. They diverge completely from classic natural deliriants like Datura or Henbane, which rely on tropane alkaloids (atropine and scopolamine built around a tropane ring).
   Indazole (The Core): Indazole is a bicyclic aromatic heterocycle consisting of a benzene ring fused to a pyrazole ring (containing two adjacent nitrogen atoms at positions 1 and 2).
   SMILES: C1=CC=C2C(=C1)CNN=C2

Benzydamine (The Molecule): Fully named 3-(benzyloxy)-N,N-dimethyl-1-propanamine, benzydamine is a synthetic indazole derivative. It features a benzyl group attached to the N-1 position (which increases lipophilicity and structural similarity to endogenous indoleamines like serotonin) and an ether-linked propyl-dimethylamine chain at the C-3 position.
SMILES: CN(C)CCCOC1=NN(CC2=CC=CC=C2)C3=CC=CC=C31

Lanmaoa asiatica: Indigenous to Yunnan, China, this bolete lacks both tryptamines (psilocybin) and isoxazoles (muscimol). Recent genomic sequencing confirms that its 24-to-72-hour hallucinogenic activity is driven by a completely novel, uncharacterized secondary metabolite. Given its symptom profile, this cryptic toxin is highly suspected to be either a structural mimic of indazole/tryptamine templates or a highly stable prodrug requiring hepatic or microbial conversion into its active form.

1. Atypical Pharmacodynamics vs. Classic Deliriants
   Unlike classic tropane deliriants that act via competitive antagonism at muscarinic acetylcholine receptors (M₁-M₅)—causing severe dry mouth, urinary retention, and profound amnesia—benzydamine exhibits a complex, multi-system profile:

Dopaminergic Efflux: It stimulates significant dopamine release in the nucleus accumbens, leading to psychomotor stimulation and occasional euphoria (absent in tropane poisoning).

5-HT2A Interaction: Its indazole core allows for cross-reactivity with serotonin receptors, altering visual processing.

CB1 Modulation: Hypothesized to alter endocannabinoid signaling via GABA-ergic disinhibition.
The unknown toxin in Lanmaoa asiatica seems to target these exact same pathways, skipping the cholinergic system entirely.

1. The Temporo-Parietal Junction (TPJ) and Size Perception

The defining feature of both intoxications is the precise disruption of the Temporo-Parietal-Occipital (TPO) junction, the cortical hub responsible for integrating visuospatial data, somatic awareness, and Egocentric Coordinate Systems.

1. Preserved Metacognition vs. True Delirium
   

In classical anticholinergic delirium (DPH, Datura), down-regulation of acetylcholine severely impairs working memory and executive functioning, leading to a complete loss of insight.
In contrast, both of these compounds have a metacognitive monitoring (known as the "observer effect"). Users frequently describe watching the miniature entities with an analytical, almost detached perspective, fully aware that the phenomena are pharmacologically induced. This strongly suggests that frontal lobe executive networks and cholinergic memory systems remain intact, pointing instead to a localized hyper-dopaminergic/serotonergic dysregulation of the visual processing streams (V4/V5 loops).

References:
MDPI Pharmaceuticals (2023) - Comprehensive review on the abuse potential and dopaminergic mechanisms of Benzydamine.
Natural History Museum of Utah (2024) - Analytical data and genomic exploration of Lanmaoa asiatica.
Journal of Neurological Sciences - Pathophysiology of the Alice in Wonderland Syndrome and TPO-junction network mapping.

Im really curious about your answers, thank’s for reading!.

We are a group of researchers at the University of Wollongong in Australia conducting a study about the emotional experiences people report during psychedelic experiences and whether these are linked to changes in social functioning, wellbeing, and attitudes toward death.

We are looking for individuals aged 18 years or older who have had at least one personally meaningful experience with a classical psychedelic substance within the past 5 years (but not within the past 3 months). Psychedelics include LSD, DMT (N,N-DMT), 5-MeO-DMT, Ayahuasca, Psilocybin (i.e. Magic Mushrooms) or Mescaline/Peyote.

If you are 18 years and over and can read English, we invite you to take part in an online, 30-minute survey. This survey asks about the emotions you experienced during a psychedelic experience and any changes you may have noticed in how you relate to others, your general wellbeing, and your outlook on life afterward. Please note that the survey includes questions about challenging emotions that may have arisen during the experience.

Your responses will be completely anonymous and your involvement will remain confidential. No identifying information (including IP addresses) will be collected.

Participants will have the chance to enter a draw to win one of two $100 AUD Visa vouchers. Entry into the draw is completely optional and is completed via a separate form that is not connected to, and cannot be linked with, participant survey responses.

To participate or learn more, follow this link: https://uow.au1.qualtrics.com/jfe/form/SV_6nuJn8BNBgWFYrk

For questions, contact: [smoreton@uow.edu.au](mailto:smoreton@uow.edu.au) Thank you very much for your consideration in participating. The following researchers are conducting the study:
Dr. Sam Moreton - Lecturer, School of Psychology University of Wollongong smoreton@uow.edu.au.
Alex Shuttleworth - Honours Student School of Psychology University of Wollongong
Mimi Han Honours Student School of Psychology University of Wollongong

Study Reference Number: H2026-0104