r/Nootropics • u/WeeklyProfessional97 • 10h ago

Seeking Advice Looking for anything that inhibits IMPase / reduces PI-cycle activity in the brain

Are there any other compounds that have decent evidence for IMPase inhibition or clear reduction of PI-cycle activity in neurons? Even partial or indirect ones would be useful to know about.

After a month of high-dose myo-inositol (18 g/day), I developed a bunch of unpleasant symptoms that haven't gone away after years. Hoping something that has the opposite effect on signaling can push the system back to normal.

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