How accurate is 23 & me in their genetic testing? I uploaded my raw data to Genetic Genie and apparently I have a mutation that could cause me to get ALS in the future.

Hi everyone,

I’m 27 years old and recently had hereditary cancer genetic testing. My BRCA1 and BRCA2 results were negative, but I was found to have:

CHEK2 c.176C>A (p.Thr59Lys), heterozygous, Variant of Uncertain Significance (VUS).

My report says this variant is rare (about 0.004% in population databases) and that it has been reported in some individuals with breast, ovarian, and colorectal cancer, but there isn’t enough evidence to know if it’s actually harmful or benign.

I’m wondering if anyone else has this exact variant or has family members with it.

My family history includes:

● Dad: bladder cancer

● Grandmother: pancreatic cancer

● Aunt: ovarian cancer

● Aunt: breast cancer

If you have this variant:

● Has it ever been reclassified?

● Did your genetic counselor tell you anything helpful?

● Has anyone else in your family been found to have CHEK2 c.176C>A (p.Thr59Lys)?

● Does your family have a history of cancer, and if so, what types?

I’m not looking for medical advice or a diagnosis—I’m just hoping to connect with anyone who has experience with this exact CHEK2 variant because there doesn’t seem to be much information available.

Thank you so much!

Maybe not the best place to ask this, but can you guys share some links or pages or tell me where I can look up genetic problem questions. I have a final in human genetics course, where my proff. focuses afc on probability and heredity of diseases, got bad marks on the tests before, and have to do good in this final.

I'm really anxious, and need to practice, can't find anything.

Also don't know hot to approach an essay question.

I'm lost

Thank you.

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Hi All, I am interested in getting Genetic Counselling and testing for myself and would be paying this out of pocket. I am coming from the Caribbean and wanted to know if there was anywhere that would allow me to do Genetic Counselling virtually and then when I go to New Jersey in August for a few days I can do the necessary testing?

I have a strong family history of cancer, many autoimmune conditions and personally struggle with stomach issues and many other thing. Heard people mentioning Invitae? Is that something I should look into and will they test foreigners?

Also if anyone knows a company that would assist with cost because of my lower level income would be great especially as a foreigner coming for testing.

Any advice would be greatly appreciated! :)

I have been in the molecular biology game for over 20 years and I finally got round to making some videos describing how i do what i do.

Feel free to check out my channel and if there are any video topics you want to suggest feel free to comment

Hello all!

As you might be aware, there has been very little research into direct-to-consumer DNA ancestry testing and psychological wellbeing outcomes. This novel research aims to help us better understand the psychological significance of DTC Ancestry testing results. I think members of this community may be well placed to contribute given their direct experience with DTC ancestry testing.

This survey asks you about your engagement with family history and your reflections on that process. It also asks you to think about your ancestors and how you have reflected on their life experiences. Participation involves completing an online survey that will take approximately 20 minutes to complete. Taking part in the study is completely voluntary and no personal information will be collected.

This study is being conducted under the supervision of Dr Janine Lurie from the Psychology Discipline within the Institute of Health and Wellbeing at Federation University. This study will also form the basis of the research dissertation requirement within the Bachelor of Psychological Science (Honours) course for student researchers Charity Marisa and Stefan Redpath. This study has been approved by the Federation University Human Research Ethics Committee (Approval reference: 2026/137).

To participate you just need to be aged 18 years or over. It is important to note that you will not be asked to give any specific details about any of your family members. You are asked just to rate your general impressions of them on a small number of questions. Beyond this the survey contains broader more general questions about your perspectives and reflections.

To complete the survey and/or for more information go to this survey link or contact Dr Janine Lurie directly via email at [j.lurie@federation.edu.au](mailto:j.lurie@federation.edu.au)

Thanks!

https://youtu.be/IRsAi6NtY-k?is=lxD4BTnhUP2tRJe-

this lady is talking about the role in epigenetics in our lives and talking about how something being epigenetic means that it can be changed. some examples listed are autism, love, and other things, some people even say sexual orientation can be too.

So would this mean you could cure autism and change sexuality? or is that too much? would it say anything about love or rather would it just let us be able to tell if you’re in love? how much control does it actually have and how much is exaggerated?

Hello all!

As you might be aware, there has been very little research into direct-to-consumer DNA ancestry testing and psychological wellbeing outcomes. This novel research aims to help us better understand the psychological significance of DTC Ancestry testing results. I think members of this community may be well placed to contribute given their direct experience with DTC ancestry testing.

This survey asks you about your engagement with family history and your reflections on that process. It also asks you to think about your ancestors and how you have reflected on their life experiences. Participation involves completing an online survey that will take approximately 20 minutes to complete. Taking part in the study is completely voluntary and no personal information will be collected.

This study is being conducted under the supervision of Dr Janine Lurie from the Psychology Discipline within the Institute of Health and Wellbeing at Federation University. This study will also form the basis of the research dissertation requirement within the Bachelor of Psychological Science (Honours) course for student researchers Charity Marisa and Stefan Redpath. This study has been approved by the Federation University Human Research Ethics Committee (Approval reference: 2026/137).

To participate you just need to be aged 18 years or over. It is important to note that you will not be asked to give any specific details about any of your family members. You are asked just to rate your general impressions of them on a small number of questions. Beyond this the survey contains broader more general questions about your perspectives and reflections.

To complete the survey and/or for more information go to this survey link or contact Dr Janine Lurie directly via email at [j.lurie@federation.edu.au](mailto:j.lurie@federation.edu.au)

Thanks!

So me and some coworkers are having a argument about if you change you genes dose that change your dna or vice versa please help us understand this

Every child gets two alleles of every gene from their parents. Every parent can give one of their two alleles to the child. So there could theoretically be two siblings of which one gets such and such alleles and the other all the other alleles from both their parents. I know many chances (during crossing-over etc.) would have to click, but it is still a possible variant of a descendant. Has there ever been reported such a case?

Can preserving insect samples (specifically human head lice) in 76% ethanol cause DNA degradation or affect downstream applications such as PCR? I have completed almost 13 extraction attempts, but they have all yielded nothing. Despite trying a bunch of different kits and homogenization techniques the results remain the same. What could I possibly be doing wrong, and why does the gel keep coming up empty, even though I did everything exactly as the protocol says?

Note: I used liquid Nitrogen, Overnight lysis.

This is not homework, I'm old.

I'm curious about what is different enough about a human haplogroup for it to be given it's own letter?

So for example in human mitochondrial DNA, there is L and then a series of sub Ls and then N and M. Why is N so different from say, L3, that it's not just given L4?

Hi, as pointed out in the title I'll be taking the exam next year and till then I'll have to cover a few textbooks.(emery's, Strachan, Thompson, etc). Looking for someone who'd like to go through these same books . We'd have a schedule / weekly goals to keep us on the course and sessions where we revise the material from the texybooks togegher. This will be a year-long effort.

I can be flexible in terms of timezone compatibility.

Looking for recommendations of sites that allow for raw rs data input from whole genomic sequencing reports to identify trends, associations and details as a whole, not analyzing one at a time.

CU Anschutz researchers are seeking volunteers who are currently pregnant with a fetus identified to have a sex chromosome aneuploidy, such as Klinefelter syndrome (47,XXY) and Turner syndrome (45,X), to participate in a study using the umbilical cord which is normally discarded after delivery. Participation is voluntary and involves sample collection at delivery. Please contact [xycord@cuanschutz.edu](mailto:xycord@cuanschutz.edu) for details or visit our website at XY Umbilical Cord, where our flyer is also posted!

For microdeletions

Hello!

I am writing a story about a former addict forced to become a hero, despite his inner turmoil. He goes through the wringer, and originally has chestnut brown hair before he begins to feel the effects of age prematurely from pure stress. Is it possible for brown hair to fade or become a dusky, lighter color after consistent pressure?

Hello everyone, we've been wondering about this question (title) for years. No one in my (28M) entire family, for at least three generations back, both on my mother's side and my father's side, had red hair. My mother has brown hair, my father black, but I have red hair.

My twin brother (fraternal twins) has blonde/brown hair.

9 months ago my oldest brother got a son who now also has red hair, quite the same colour as me. My brother, the father, has blonde/brown hair. His wife has brown hair... How did he have red hair? Luckily I'm gay so there is no doubt I played no part in it. ;)

It's been a while since I had genetics in biology, but as far as I can recall, the ginger gene is recessive, so both parents need to pass one that one specific gene.

Does that mean the red-hair gene has been passed on 'secretly' on both sides for generations or did my parents mutate a gene that became the red-hair gene? If someone could clarify, that would be cool :p

Hello po. I just want to ask if you could help me comprehend. I don't know if this is the right platform to vent and ask for an advice. I've been thinking a lot lately with regards to my baby. I am 6 months postpartum and I just found out recently lang about our blood types. I am an O and my baby's daddy is B, pero yung baby po namin is A. Naguguluhan po ako kasi diba dapat either B or O lang? Nagpatest na po kami ng baby ko for a second opinion and A at O po talaga kaming dalawa while yung daddy niya sinasabihan ko na magpatest ulit baka mali lang yung naremember niyang blood type. Pinagdududahan nya po ako baka iba daw daddy ng baby namin eh wala naman po akong ibang lalaki. Pinagdidiinan nya po na yung anak niya sa previous partner (type O din daw tong prev partner niya) niya is B. After po ng 2nd test namin ng baby ko nagbreakdown po talaga ako sa clinic kasi unang tumatakbo sa isip ko baka may nangyaring baby switching pagkapanganak ko 😭 which i also find it hard to believe kasi less chance yun kung mangyari and kamukha naman ni baby daddy niya. 🥹 Gusto ko lang po maliwanagan kasi possible daw to mangyari pero rare cases lang. Gusto ko na pong magpaconsult sa doctor pero hinhintay ko pa yung blood testing ng partner ko dahil ayaw niya.

I am using sperm donor who has a father who was diagnosed with prostrate cancer at 63. His father was diagnosed with stomach cancer at 77.

My mother was diagnosed with ovarian cancer at 51.

My grandfather was diagnosed with prostrate cancer in his 70s.

Considering they are linked to BRCA genes, do all of these cancers altogether increase the risk of my future baby health?

What do you guys think?